CNDAC hydrochloride

Research use only, not for human use.

CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.

CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.

Cell Viability Assay Cell Line:Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cellsConcentration:0-1 μMIncubation Time:24 h Result:Inhibited cell survival with IC50s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.Cell Proliferation Assay Cell Line:HL-60 and THP-1 cells Concentration:0-100 μM Incubation Time:3 days Result:Inhibited proliferation with IC50s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.Apoptosis Analysis Cell Line:HL-60 and THP-1 cells Concentration:0, 0.5, 1, 2, 3, 4, 5 and 10 μM Incubation Time:3, 4, 5, and 6 days Result:Induced apoptosis in both cells.Cell Cycle Analysis Cell Line:HCT116 Concentration:6?μM Incubation Time:48?h Result:36 and 36% of cells were arrested in late-S and G2/M phases, respectively.

Animal Model:CDF1 mice, P388 tumor modelDosage:20 mg/kg Administration:Intraperitoneal injection, daily for 10 days Result:Greatly increased the survival time and survival rate.

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Others

Other Targets

Others

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134665-72-8

288.69

C10H13ClN4O4

>98% (HPLC)

DMSO:123 mg/mL (426.06 mM; Need ultrasonic)

Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2C#N

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(-20℃)

With Ice Pack

≥ 2 years